Best Peptides for Cardiovascular

Peptides studied for heart health, blood pressure, lipid profiles, and vascular function.

12 peptides ranked by research effectiveness

01

VIP

Extensively Studied

Vasoactive Intestinal Peptide | Neuropeptide

Pulmonary Hypertension most effective
Vasodilation most effective
Cardiac Support effective
Half-life: 1-2 minutes
02

Retatrutide

Extensively Studied

Triple GLP-1/GIP/Glucagon Agonist | Weight Loss & Diabetes

Lipid Improvement effective
Blood Pressure Optimization effective
Hepatic Fat Reduction most effective
Half-life: ~6 days
03

Tirzepatide

FDA Approved

Dual GIP/GLP-1 Receptor Agonist | Weight Loss & Diabetes

MACE Reduction effective
Blood Pressure Reduction effective
Lipid Profile Improvement moderate
Half-life: ~5 days (120 hours)
04

SS-31

Well Studied

Mitochondrial-Targeted Peptide | Cardiolipin Protector

Cardiac Protection effective
Heart Failure Support effective
Exercise Tolerance effective
Half-life: ~2 hours
05

Hexarelin

Well Studied

Examorelin | Synthetic Growth Hormone Secretagogue

Cardioprotection effective
Cardiomyocyte Protection moderate
Calcium Channel Modulation moderate
Half-life: 1-2 hours
06

Mazdutide

Extensively Studied

Dual GLP-1/Glucagon Receptor Agonist | Weight Loss & Diabetes

Blood Pressure Reduction effective
Lipid Profile Enhancement effective
Half-life: 6-8 days
07

Cardiogen

Moderate Research

AEDR | Cardiovascular Bioregulator Peptide

Cardiac Tissue Repair effective
Myocardial Function moderate
Cardiovascular Aging moderate
Half-life: Minutes (short peptide); effects persist via epigenetic changes
08

Vesugen

Moderate Research

KED | Vascular Bioregulator Peptide

Vascular Aging effective
Atherosclerosis Prevention moderate
Endothelial Function moderate
Half-life: Not established
09

Thymosin Beta-4

Well Studied

43-Amino Acid Regenerative Peptide | Tissue Repair & Healing

Cardiac Protection Post-MI effective
Half-life: Dose-dependent; relatively short (exact values not established)
10

TB-500 (Ac-LKKTETQ)

Moderate Research

Thymosin Beta-4 Active Fragment | Healing Peptide

Angiogenesis effective
Half-life: Not precisely established; effects persist longer than 24 hours
11

AICAR

limited

5-Aminoimidazole-4-carboxamide Ribonucleotide | AMPK Activator

Ischemia Protection moderate
Half-life: ~2-3 hours
12

SLU-PP-332

Emerging

Synthetic Pan-ERR Agonist | Exercise Mimetic & Metabolic Modulator

Cardiac Function Improvement moderate
Half-life: Under investigation (no human PK data)

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