Best Peptides for Muscle Growth

Peptides studied for lean mass development, muscle protein synthesis, and body composition.

16 peptides ranked by research effectiveness

01

HGH

FDA Approved

Human Growth Hormone | Somatropin

Fat Loss effective
Lean Mass effective
Recovery Enhancement effective
Half-life: 3-4 hours (SC), 20-30 minutes (IV)
02

IGF-1 LR3

limited

Modified Growth Factor Analog | Muscle Growth

Hypertrophy most effective
Anti-Catabolic effective
Hyperplasia effective
Half-life: 20-30 hours
03

MK-677

Well Studied

Ghrelin Receptor Agonist | Oral Growth Hormone Secretagogue

Muscle Preservation most effective
Fat-Free Mass effective
Metabolic Rate effective
Half-life: ~24 hours
04

Tesamorelin

FDA Approved

GHRH Analog | Visceral Fat Reduction

Lean Mass Preservation moderate
IGF-1 Elevation moderate
Half-life: 26-38 minutes
05

GHRP-6

Well Studied

Growth Hormone Releasing Peptide-6 | Hexapeptide GHS

Muscle Growth effective
Appetite Stimulation most effective
Recovery Enhancement effective
Half-life: 15-60 minutes
06

Sermorelin

Well Studied

GHRH Analog | Growth Hormone Releasing Hormone

Lean Body Mass Enhancement most effective
IGF-1 Mediated Growth effective
Athletic Recovery effective
Half-life: 10-12 minutes
07

Erythropoietin (EPO)

Extensively Studied

EPO | Red Blood Cell Stimulating Hormone

Endurance Enhancement most effective
Altitude Acclimatization effective
Half-life: 4-12 hours (IV), ~25 hours (SubQ)
08

MGF

limited

Mechano Growth Factor | IGF-1 Splice Variant

Satellite Cell Activation most effective
Local Muscle Recovery effective
Post-Exercise Recovery effective
Half-life: ~5-7 minutes
09

PEG-MGF

limited

Pegylated Mechano Growth Factor | IGF-1 Splice Variant

Satellite Cell Activation most effective
Delayed Senescence effective
Enhanced Fusion Potential effective
Half-life: 48-72 hours (via PEGylation)
10

GHRP-2

Well Studied

Growth Hormone Releasing Peptide-2 | Pralmorelin

Muscle Growth effective
Fat Metabolism effective
Recovery Enhancement effective
Half-life: ~30 minutes
11

CJC-1295 with DAC

Well Studied

Long-Acting Growth Hormone Releasing Hormone Analog | Extended Release

Fat Loss Enhancement effective
Lean Mass Gains effective
Half-life: 6-8 days
12

Ipamorelin

Well Studied

Growth Hormone Secretagogue | Selective GHRP

Lean Mass Development effective
Fat Loss Support effective
Half-life: ~2 hours
13

MOTS-c

Well Studied

Mitochondrial-Derived Peptide | Metabolic Regulator

Running Performance moderate
Muscle Homeostasis moderate
Recovery Support moderate
Half-life: ~30 minutes
14

SLU-PP-332

Emerging

Synthetic Pan-ERR Agonist | Exercise Mimetic & Metabolic Modulator

Endurance Improvements effective
Muscle Fiber Remodeling effective
Half-life: Under investigation (no human PK data)
15

AICAR

limited

5-Aminoimidazole-4-carboxamide Ribonucleotide | AMPK Activator

Endurance Enhancement moderate
Mitochondrial Biogenesis moderate
Half-life: ~2-3 hours
16

L-Carnitine

established

Amino Acid Derivative | Fatty Acid Transporter

Exercise Recovery moderate
Endurance Support moderate
Half-life: ~2-3 hours (injectable)

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