Best Compounds for Anti-Aging & Longevity

Peptides studied for cellular protection, telomere maintenance, skin rejuvenation, and age-related decline.

32 compounds ranked by research effectiveness

01

Rapamycin

FDA Approved

mTOR Inhibitor | Longevity & Immunosuppression

Geroprotection (Lifespan Extension) most effective
Autophagy Enhancement most effective
Immunosenescence Reversal effective
Periodontal Disease / Oral Health effective
Cognitive Decline moderate
Cardiac Aging moderate
Half-life: ~62 hours
02

Epitalon

Well Studied

Synthetic Pineal Tetrapeptide | Telomerase Activator

Telomere Extension most effective
Cellular Rejuvenation most effective
Lifespan Extension effective
Half-life: Not established (short peptide)
03

NAD+

Extensively Studied

Essential Cellular Coenzyme & Anti-Aging Therapy

DNA Repair effective
Sirtuin Activation effective
Cellular Senescence Reduction moderate
Half-life: 1-4 hours (intracellular)
04

NMN

Moderate Research

NAD+ Precursor | Cellular Energy & Longevity

NAD+ Restoration effective
Sirtuin Activation effective
DNA Repair Support moderate
Half-life: ~2-3 hours (oral)
05

Metformin

FDA Approved

Biguanide | AMPK Activator & Longevity Research

Geroprotection / Healthspan Extension under research
Cancer Risk Reduction under research
Cardiovascular Protection effective
Half-life: ~5 hours
06

Humanin

Moderate Research

Mitochondria-Derived Peptide | HN

Lifespan Extension effective
Healthspan Improvement effective
Anti-Aging moderate
Cytoprotection effective
Anti-Apoptosis effective
Mitochondrial Support effective
Half-life: ~30 minutes (mice), >4 hours (rats)
07

Thymalin

Well Studied

Thymic Peptide Bioregulator | Immune Modulator

Mortality Reduction most effective
Geroprotection effective
Combined Protocol most effective
Half-life: Not established (complex mixture); effects persist for weeks
08

5-Amino-1MQ

preclinical

NNMT Inhibitor | Longevity & Metabolic Enhancement

NAD+ Enhancement most effective
Mitochondrial Function most effective
Cellular Repair effective
Half-life: 4-7 hours (3.8h IV, 6.9h oral)
09

Glutathione

Extensively Studied

L-Glutathione | Master Antioxidant Tripeptide

Oxidative Stress Reduction most effective
Heavy Metal Detoxification effective
Liver Support effective
Half-life: ~10-14 minutes (IV)
10

MOTS-c

Well Studied

Mitochondrial-Derived Peptide | Metabolic Regulator

Age-Related Decline Reversal effective
Mitochondrial Biogenesis effective
Lifespan Extension effective
Half-life: ~30 minutes
11

PT-141

FDA Approved

Melanocortin Receptor Agonist | Sexual Dysfunction Treatment

Sexual Distress Reduction effective
Sexual Satisfaction effective
Half-life: ~2.7 hours
12

CJC-1295 (without DAC)

Well Studied

Short-Acting Growth Hormone Releasing Hormone Analog

Muscle Mass Preservation effective
Bone Density Maintenance effective
Skin Elasticity moderate
Half-life: 30 minutes - 2 hours
13

Sermorelin

Well Studied

GHRH Analog | Growth Hormone Releasing Hormone

Age-Related GH Decline Reversal effective
Body Composition Improvement effective
Skin Quality Enhancement moderate
Half-life: 10-12 minutes
14

Thymogen

Well Studied

EW Dipeptide | Thymus Immune Bioregulator

Geroprotection effective
Lifespan Extension effective
Antitumor Activity moderate
Half-life: Not established
15

FOXO4-DRI

Emerging

Senolytic Peptide | p53-FOXO4 Disruptor

Senescent Cell Clearance effective
Tissue Rejuvenation effective
Physical Function effective
Half-life: Not established
16

HGH

FDA Approved

Human Growth Hormone | Somatropin

Skin and Hair Quality moderate
Energy and Well-being moderate
Half-life: 3-4 hours (SC), 20-30 minutes (IV)
17

Livagen

Moderate Research

KEDA Tetrapeptide | Liver Bioregulator

Chromatin Remodeling effective
Age-Related Liver Decline effective
Gene Activation moderate
Half-life: Not established
18

Prostamax

Moderate Research

KEDP Tetrapeptide | Prostate Bioregulator

Chromatin Remodeling effective
Gene Reactivation moderate
Lymphocyte Function moderate
Half-life: Not established
19

SS-31

Well Studied

Mitochondrial-Targeted Peptide | Cardiolipin Protector

Age-Related Muscle Function moderate
Cognitive Protection moderate
Cellular Rejuvenation moderate
Half-life: ~2 hours
20

Vesugen

Moderate Research

KED | Vascular Bioregulator Peptide

SIRT1 Activation effective
Stem Cell Activation moderate
Cellular Rejuvenation moderate
Half-life: Not established
21

Vilon

Moderate Research

KE Dipeptide | Thymus Immune Bioregulator

Lifespan Extension effective
Tumor Suppression moderate
Tissue Regeneration moderate
Half-life: Not established
22

Pinealon

Well Studied

Synthetic Tripeptide | Neuroprotection & Cognitive Enhancement

Cellular Senescence Reduction moderate
Biological Age Markers moderate
Half-life: Not established
23

Thymosin Alpha 1

Well Studied

Synthetic Thymic Hormone | Immune System Modulator

Thymic Regeneration Support moderate
Immune Senescence Delay moderate
Half-life: ~2 hours
24

Bronchogen

Moderate Research

AEDL Tetrapeptide | Bronchial Bioregulator

Respiratory Aging moderate
Gene Expression moderate
Half-life: Minutes (short peptide); effects persist via epigenetic changes
25

Cardiogen

Moderate Research

AEDR | Cardiovascular Bioregulator Peptide

Epigenetic Regulation moderate
Tissue Regeneration moderate
Half-life: Minutes (short peptide); effects persist via epigenetic changes
26

Chonluten

Moderate Research

EDG Tripeptide | Bronchial/Lung Bioregulator

Geroprotection moderate
Gene Expression Regulation moderate
Half-life: Minutes (short peptide); effects persist via epigenetic changes
27

Cortagen

Moderate Research

AEDP | Brain Cortex Bioregulator Peptide

Oxidative Balance moderate
Brain Aging moderate
Half-life: Minutes (short peptide); effects persist via epigenetic changes
28

Ovagen

Moderate Research

EDL Tripeptide | Liver & GI Bioregulator

Liver Aging moderate
GI Aging moderate
Half-life: Not established
29

CJC-1295 with DAC

Well Studied

Long-Acting Growth Hormone Releasing Hormone Analog | Extended Release

Recovery Enhancement moderate
Half-life: 6-8 days
30

Vesilute

Moderate Research

ED Dipeptide | Bladder & Urinary Tract Bioregulator

Urogenital Aging moderate
Tissue Regeneration emerging
Half-life: Not established
31

Pancragen

Moderate Research

KEDW Tetrapeptide | Pancreas Bioregulator

Gene Expression Regulation moderate
Half-life: Not established
32

SLU-PP-332

Emerging

Synthetic Pan-ERR Agonist | Exercise Mimetic & Metabolic Modulator

Mitochondrial Aging Reversal moderate
Half-life: Under investigation (no human PK data)

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